HDAC's at Work

Metabolic Homeostasis: HDACs Take Center Stage

Hormonal regulation of glucose and lipid metabolism is pivotal for metabolic homeostasis and energy balance. Two studies in this issue of Cell (Mihaylova et al., 2011 and Wang et al., 2011) introduce a new conserved signaling mechanism controlling catabolic gene expression: class IIa histone deacetylases (HDACs) regulate Foxo activity in Drosophila and mice.

Acute promyelocytic leukemia: STATs, HATs, and HDACs

In this issue, both Dong and Tweardy (page 2637) and Maurer et al (page 2647) offer a detailed functional and biochemical characterization of the Stat5b-RARa fusion protein, which was originally described in a patient with acute promyelocytic leukemia (APL) several years ago (Arnould et al, Hum Mol Genetics. 1999;8:1741-1749). Stat5b is one of 5 genes that have now been identified as fusion par...

Fixed-term work and violence at work.

OBJECTIVES This study investigated the effect of a fixed-term job contract on encounters of violence at work. We assumed that fixed-term employees encountered more violence or threats of violence at their work than permanent employees. METHODS This study is based on 3 large statistical data sets: (a) the Work and Health surveys carried out by the Finnish Institute of Occupational Health in 19...

Coparticipation at work: Knowing and work practicer

The spreading influence of platelet HDACs.

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